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Salivary secretion depends on finely tuned receptor activity, and sustained activation may paradoxically reduce glandular responsiveness, contributing to the salivary hypofunction

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The mainstay of treatment is an aggressive surgical approach with negative margins (R0 resection) followed by adjuvant radiotherapy for tumors with high grade, large size, and positive margins and the addition of chemotherapy for those who can tolerate it [3]

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