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Indeed, GSTP1 expression can predict pathological response to chemotherapeutic treatments with 5-fluorouracil/epirubicin/cyclophosphamide in ER-negative tumors but not in ER-positive tumors

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Matta K, Lefebvre T, Vigneau E, Cariou V, Marchand P, Guitton Y, et al

In 56-week studies, patients taking Contrave alongside diet and exercise lost an average of 5-9% of their body weight, compared to 1-5% with a placebo, meaning the medication contributed roughly 4-5 percentage points of additional weight loss.4,5 About 46% of patients on Contrave achieved at least 5% weight loss by week 16