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A proteomic platform to identify off-target proteins associated with therapeutic modalities that induce protein degradation or gene silencing

5a), approved for the treatment of amyotrophic lateral sclerosis, increases ROS levels by multiple mechanisms, including decreasing LDH-A and NAD + levels to increase oxidative stress, as well as interfering with the xCT antiporter to block the cystineglutamate pump

Glutathione is a potent antioxidant that plays an important role in protecting cells from oxidative damage

This type typically manifests in early childhood and is characterized by progressive muscle weakness and wasting, leading to difficulties with mobility and motor functions