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In epilepsy, this interplay is evident in models such as the lithium-pilocarpine (Li-Pilo) model of SE, which recapitulates key features of epileptogenesis including altered glucose metabolism (Dank et al., 2022) and mitochondrial bioenergetics with increased markers of oxidative damage (Carrasco-Pozo et al., 2015
Vanderheyden, M
DOAC medications (apixaban, rivarelbanan) are less affected by absorption timing changes
A 2025 study published in Obesity found that semaglutide-induced weight loss improved mitochondrial oxidative phosphorylation efficiency in skeletal muscle in mice meaning GLP-1 medications may independently support some mitochondrial improvements through weight loss itself
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