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Acknowledgements This work was supported by grants from the National Institute of Health (NIH R01HL145031 for ZI, NW, RS, LB, MLY, J.PA., OBU and NIH R21GM136002 for MLY and OBU) and National Science Foundation (NSF EEC-1941543 for ZI, EC, MLY, OBU)

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Published data suggests up to 2.6% incidence of B12 deficiency within a year of treatment, and this figure climbs in patients who have used these medications long term or combined them with very low calorie diets (3)

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