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Immunobiology 215(910):788795

If nausea, vomiting, or constipation become severe, a doctor may suggest changes such as adjusting the dosage or taking medication to relieve symptoms

For example, a 12-week study of patients randomized to olanzapine 15 mg plus metformin 750 mg (n = 20), vs olanzapine 15 mg plus placebo (n = 20), found that the 63% of patients taking olanzapine + placebo increased their weight by more than 7% vs only 17% of patients taking olanzapine + metformin (Wu RR et al, Am J Psychiatry 2008;165(3):352358)

Psychological and behavioural risks : Combining multiple weight loss interventions may foster unhealthy relationships with food, promote disordered eating patterns, and create unrealistic expectations about sustainable weight management