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However, in the context of oxidative stress and limited GSH availability, microglia can become pathologically overactive which contributes to chronic inflammation and neuronal damage

GR requires NADPH as a cofactor to perform this conversion, creating a sophisticated enzymatic system that regenerates our antioxidant resources

Wang W, Kryczek I, Dostl L, Lin H, Tan L, Zhao L et al

however, when compared with results in the control group, cosupplementation using VD with LC significantly increases GSH levels and reduces oxidative stress, TNF-, and IR levels in blood, and increases GSH levels and reduces oxidative stress in liver and muscle