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[52] showed that a 12-month treatment with sitagliptin significantly decreased systolic [( 7.0 18.9) mmHg] and diastolic [( 5.1 11.7) mmHg] blood pressure in patients with both T2DM and cardiovascular risk factors

BCKA treatment increased production of pro-inflammatory cytokines (MCP-1, TNF-) (75)

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This balanced activity is one reason tirzepatide has generated such a large body of comparative research it gives investigators a clear reference point when studying how dual-receptor engagement differs from single-receptor GLP-1 compounds