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The SUSTAIN trials reported DR worsening in some Semaglutide-treated patients, particularly those with pre-existing DR 23
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In clinical trials such as SURPASS and SURPASS-2, tirzepatide demonstrated comparable or superior efficacy to semaglutide in improving HbA1c and reducing BMI, with weight reductions of 5.4 to 10.5 kg and up to 2.34% HbA1c reduction at 40 weeks.16,17 Tirzepatide is administered as a weekly injection beginning at 2.5 mg weekly and increasing to 5 mg after four weeks
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