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In well-resourced countries, three potential treatments are available for preventing or reducing the morbidity and mortality associated with SCA: transfusions, hydroxyurea, and stem cell transplantation [89]

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[79] When used together with alpha-blockers, no benefit was reported in short-term trials, but in a longer-term study (34 years) there was a greater reduction in BPH progression to acute urinary retention and surgery than with either agent alone, especially in people with more severe symptoms and larger prostates

doi:10.1074/jbc.M112.418046 Lothrop AP, Snider GW, Ruggles EL, Hondal RJ (2014) Why is mammalian thioredoxin reductase 1 so dependent upon the use of selenium