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Residues forming this surface cleft and cavity come from both the N-terminal domain (Tyr10, Phe11, Phe13 Arg16, Met38) and from the C-terminal domain (Glu103, Asp104, Tyr106, Arg107, Tyr110, Phe113, Arg114)

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Your provider may recommend extending your adjustment timeline, switching to oral semaglutide, or exploring the Precision Peptide Genetic Test to identify genetic factors influencing your tolerance