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Moreover, the ICRS visual histological scores 51 , osteoarthritis cartilage histopathology assessment system (OARSI) 52 , hyaline cartilage defect distance, and relative expression of COL II were quantitively evaluated based on the results of H&E staining, toluidine blue staining, Safranin O/Fast Green staining, and COL II immunohistochemical staining, respectively

However, not all vitamin C creates this problem

Oncotarget 6 , 54655474 (2015)

In manufacturing, CanSinoBIO has implemented a safer production process featuring animal component-free fermentation media and phenol-free purification technology, thereby eliminating risks associated with animal-derived materials and toxic residues while preserving vaccine immunogenicity.