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Constipation may also prolong contact with biliary metabolites and allow more deconjugation and reabsorption

Fibrosis risk assessment In line with NICE guideline NG49, GPs may use the FIB-4 score to stratify risk: a score below 1.3 generally indicates low risk of advanced fibrosis, whilst a score above 2.67 (or above 2.0 in patients aged over 65) warrants further assessment, typically with enhanced liver fibrosis (ELF) testing or referral to hepatology

Takane's figures for rodent data and the figure on the following page for human data)

The region of the H-NMR spectrum related to the N-acetyl groups (2.151.90 ppm) was deconvoluted using three Lorentzian functions in order to calculate the specific concentrations of N-acetylglucosamine and N-acetyl galactosamine (GlycA) and N-acetylneuraminic acid (GlycB) [37]