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Lastly, despite PDE5i treatment has been proven a cost-effective therapeutic strategy, compared to no treatment [62], the relatively high cost of a chronic treatment with some reference/equivalent pharmaceutical formulations belonging to this category of drugs might still represent a limitation for patients with economic constraints, by contributing to treatment discontinuation

The recently published phase-3 clinical trials data of the drug donanemab, which targets amyloid plaque, have shown to reduce cognitive decline in AD patients, but also cause brain haemorrhage (bleeding) and edema (swelling) in some of these patients

An immunohistochemical study demonstrated that Pue@GelMA successfully altered the immunological milieu by reducing neutrophil and eosinophil aggregation and altering the ECM collagen distribution (Qin et al

After six months, no significant changes were noted in the placebo group