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One study published in The New England Journal of Medicine found that participants who took Semaglutide lost an average of 14.9% of their body weight over a period of one year, compared to 2.4% in the placebo group

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J Endocrinol 221(1):T1T16 Heppner KM, Marks S, Holland J et al (2015) Contribution of brown adipose tissue activity to the control of energy balance by GLP-1 receptor signalling in mice