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Temperature Extremes: Exposure to extreme temperatures, whether hot or cold, can cause skin redness

10.1111/jcmm.13230 13 CarnesecchiS.DeffertC.DonatiY.BassetO.HinzB.Preynat-SeauveO.et al (2011)

2,97 Studies and clinical practice of treatment of pernicious anaemia with regular high-dose injections has confirmed the safety of B12 at high dosages, and therefore neither the Institute of Medicine (IOM) in the USA nor the European Food Safety Agency (EFSA) have set an upper limit