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Higher Discontinuation Rates: The triplet therapy group had a 28.3% discontinuation rate due to tolerability issues and adverse events, significantly higher than the 4% to 10% seen in the semaglutide-only or semaglutide + trevogrumab groups

Journal der Deutschen Dermatologischen Gesellschaft

17 Statement #13: strong recommendation, low quality evidence (1C) Neurodevelopmental prognosis is mainly dependent on total duration of coma, peak ammonia levels, and number of episodes of hyperammonemia