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Misuse, he said, raises the risk of side effects and inappropriate dosage, adding that regulators and companies must tighten prescription controls and promote awareness

The companies analyzed in the report include Eli Lilly and Company, Pfizer, Sanofi, AstraZeneca PLC, Boehringer Ingelheim, and Novo Nordisk

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In contrast, other agonists that exhibit stable open TM6/ECL3/TM7/TM1 conformations, including exendin-P5, are correlated with a bias towards G protein-mediated signalling