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Intriguingly, although SF3B1 does not possess a direct role in MAPK pathway signal transduction, there is little overlap between tumors with MAPK pathway mutations and SF3B1 -mutated tumors, suggesting that SF3B1 mutations possibly lead to splicing variations of specific genes that can lead to MAPK activation (118)

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Create a restful environment by minimizing noise, limiting screen time before bed, and using blackout curtains if needed to avoid disrupted sleep