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Generic and biosimilar timeline The pharmaceutical patent landscape suggests that generic and biosimilar versions of current GLP-1 medications will eventually enter the market, though not immediately

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While buccal absorption is less efficient than sublingual, it is still better than sending the compound straight to the stomach

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2024 Meta-Analysis Indicates That GLP-1RAs Reduce Adverse CV Events GLP1-RA therapy significantly reduces the risk of major adverse cardiovascular events (MACEs), all-cause mortality, CV mortality, stroke, risk for coronary revascularization, and composite adverse kidney outcomes in both sexes, regardless of a patient's history of cardiovascular disease, BMI or eGFR (Rivera et al, 2024)

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