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Negotiating these contracts requires understanding interchangeability designations, which FDA grants separately from biosimilar approval and which permit automatic substitution at the pharmacy level without a new prescription

Therapeutic categories where physicians are reluctant to substitute certain anti-epileptics, thyroid drugs, and immunosuppressants with narrow therapeutic indices also see slower branded erosion

Its crucial not to discontinue prednisone abruptly due to the risk of adrenal insufficiency

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