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[10] NAD+ Injection is generally reported to be well-tolerated, with a low incidence of serious adverse effects

The accumulation of lipids in adipocytes causes nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activation, which exacerbates ROS production

The investigation was conducted in accordance with the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) reporting guidelines

The childhood-onset obesity is also a trigger for severe complications during adult age, in particular body composition and endocrine alterations [8, 9], including growth hormone (GH) deficiency (GHD) [9], hypothyroidism [10], hypogonadism [11], and leptin resistance [12]