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Oral GLP-1 formulations are adding manufacturing complexity in a different dimension: on December 22, 2025, the FDA approved Novo Nordisk's oral Wegovy 25 mg as the first oral GLP-1 therapy for weight loss, bringing with it the manufacturing requirements of oral solid dosage pharmaceutical production at commercial scale, a fundamentally different infrastructure challenge from parenteral peptide API synthesis

(PubMed) Kumaran S, Subathra M, Balu M, Panneerselvam C

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Compounded semaglutide at roughly $240 per month produces approximately 15% weight loss, working out to about $16 per month per percentage point of weight loss