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The android fat distribution pattern may be justified by hyperandrogenism, resulting in a vicious circle of central adiposity, hyperinsulinism, and metabolic aberrations ( Polycystic Ovary Syndrome (PCOS) PCOS is a recurrent reproductive endocrinological disorder that affects up to 20% of women of reproductive age globally ( 3 ovarian volume) ( The insulin-like growth factor-I receptor (IGF-IR) could also be involved in the mechanism of hyperandrogenism induced by hyperinsulinemia observed in PCOS patients

For instance, CUL5 promotes AQP1 degradation via the ubiquitin-proteasome system, reducing cellular water permeability (142)