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1 In practice: Take your levothyroxine first thing in the morning with water, at least 30-60 minutes before food or other medications Dont take your Mounjaro injection at the same time of day as your levothyroxine If you inject Mounjaro in the morning, consider taking your levothyroxine at bedtime instead (at least two hours after your last meal), or vice versa Theres no formal drug interaction listed between tirzepatide and levothyroxine