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For example, a brain-permeable TNF- inhibitor significantly altered hippocampal protein expression in a 3xTg AD model, revealing region-specific feasibility

Krivic et al., 2008) ligament-healing (Cerovecki et al., 2010) and has a strong osteogenic effect the in non-union model (Sebecic et al., 1999) (and in other models, such as is observed with rat femoral head osteonecrosis (Gamulin et al., 2013), or alveolar bone loss (Keremi et al., 2009)

(PubMed) Leach NV, Dronca E, Vesa SC, et al