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[DOI] [PMC free article] [PubMed] [Google Scholar] 80.Negre-Salvayre A., Guerby P., Gayral S., Laffargue M., Salvayre R

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The STEP-HFpEF trial was the first RCT to specifically target obese HFpEF patients [101]

The physiological stress of rapid weight loss can disrupt neurotransmitter balance, potentially triggering emotional instability, especially in individuals with pre-existing vulnerabilities like my own bipolar disorder, which can be simply explained as is a faulty wiring in the brains mood control system