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For correlation analysis, we computed the pair-wise Pearson correlation coefficient and the corresponding p -value between the expression levels of two genes using MATLAB

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SAMe is considered to be the universal methyl donor for all methylation reactions including donating a methyl group for DNA and RNA, proteins and neurotransmitters

The case studys pharmacological intervention was the administration of semaglutide following the standard titration protocol: the patient was first prescribed 0.25 mg subcutaneously once weekly in August 2024