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An unexpected finding of Chen et al.'s study was that G6PD knock-out animals have impaired folate metabolism since methylenetetrahydrofolate reductase (MTHFR) converts 5,10-methylenetetrahydrofolate to 5-methyl-tetrahydrofolate, a cosubstrate for homocysteine remethylation to methionine [125]

2015;173:M8597

Cognitive impairments can arise from various causes, including viral infections (e.g., HIV), traumatic brain injury, neurodegenerative diseases (e.g., Alzheimers disease, AD), autoimmune disorders (e.g., multiple sclerosis), and immune-related processes [3,4]

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