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484,485 UPS dysregulation in SLE: autoantibodies, antigen processing, and immune signaling In SLE, aberrant UPS activity contributes to inflammatory pathways, defective antigen presentation, and impaired apoptotic processes

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Gastrointestinal Side Effects: Patients may experience gastrointestinal side effects such as nausea and diarrhea, particularly during the initial phase of treatment, which could impact adherence