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Direct interaction of FBF with GLD-3 that might underlie this function is discussed further in section Protein Cofactors That Change PUF Regulatory Outcome. The fact that PUF proteins appear to regulate both proliferation and differentiation is enigmatic and has promoted several interpretations

The same study found that the most common reasons patients stop GLP-1 therapy are adverse effects (52%), medication shortages (33%), and cost (25%)