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Gastrointestinal adverse effects are the most frequently reported and include: Nausea (very common, affecting more than 1 in 10 people according to the SmPC) Vomiting Diarrhoea Constipation Abdominal pain or discomfort These symptoms are usually mild to moderate, transient, and tend to improve over time as the body adjusts to the medication

Khan MS, Fonarow GC, McGuire DK et al (2020) Glucagon-like peptide 1 receptor agonists and heart failure: the need for further evidence generation and practice guidelines optimization

The flexible linker ensures spatial separation between the Fc region and the GLP-1 receptorbinding domain, preserving receptor accessibility and bioactivity

Meng X, Song Q, Liu Z et al (2024) Neurotoxic -amyloid oligomers cause mitochondrial dysfunctionthe trigger for PANoptosis in neurons