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Compare to healthy cells, cancer cells are characterized by increased formation of ROS and therefore to avoid ROS-induced cell death, cancer cells restore their ROS homeostasis by increasing their antioxidant capacity (Valko et al

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This research informs the broader peptide-metal-complex field, including investigations of analog HGK:Cu (223-fold higher SOD-mimetic activity) and copper-binding PIP-tides.[3] Ferritin Iron-Blockade and Lipid Peroxidation Research Cell-free and cell-culture investigations use GHK-Cu to probe whether copper-tripeptide complexes can prevent iron release from ferritin and downstream membrane lipid peroxidation