Cremonini E, Daveri E, Mastaloudis A, Oteiza PI
One notable behavioral reaction: a small number of participants were reportedly reluctant to continue the study because the weight loss felt too extreme, though such reports are anecdotal and not a formal safety signal
Accordingly, whereas PPAR agonists (fibrates) are classically assumed to improve lipid and cholesterol metabolism via their action on the liver, agonists at PPAR (thiazolidinediones) are assumed to improve insulin sensitivity by enhancing adipose tissue differentiation and fatty acid uptake 10,11,23
Common deficiencies among GLP-1 users include Vitamin B12, Vitamin D, iron, calcium, and fat-soluble vitamins A and E, all nutrients that become harder to consume in adequate amounts when food intake is significantly reduced