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The lack of the main binding interaction with the Asp residue in Ab Pcob may explain the absence of any obvious spectral shift and increase in absorbance at 700 nm upon BV binding that is observed for Sas Pcob (Fig

We used the Register of Laboratory Results for Research [14] to obtain measurements of hemoglobin A1c, plasma creatinine, albumin/creatinine ratio in urine, and estimated glomerular filtration rate (Supplementary Table 1)