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lipoatrophic diabetes, Wolfram syndrome, Down syndrome, Klinefelter syndrome (XXY males), Turner syndrome, type 1 myotonic dystrophy, muscular dystrophy, Huntington disease, Friedreich ataxia, Prader-Willi syndrome, Werner syndrome, Cockayne syndrome, and others such as those indicated above

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Polyphenols also regulate immune cell function by modulating the activity of dendritic cells, lymphocytes, and macrophages (274, 275)

The proteomic data showed that various antioxidant enzymes such as glutathione S-transferase theta 2 (GSTT2), glutathione S-transferase Mu 1 (GSTMI), and glutathione S-transferase alpha 1/2/5 (GSTA1/2/5) were upregulated in male mice livers treated with ibuprofen compared to controls (Fig