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Fresh rat blood was obtained prior to each experiment via jugular vein catheters from adult male Sprague-Dawley rats

Tirzepatide produced 20.2% weight loss versus 13.7% for semaglutide at 72 weeks and has stronger body-composition results. Semaglutide has the longer safety history, cardiovascular outcomes data, kidney outcomes data, and an oral formulation. Oral semaglutide What about oral semaglutide (Rybelsus)

However, due to the exploratory character of the study and relatively small study size, the findings remain to be confirmed in future studies with larger sample sizes