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Further investigation has revealed that FANCD1 is the same gene as BRCA2 , a gene that causes predisposition to breast and ovarian cancer.[181] Other Fanconi anemia genes, FANCJ ( BRIP1 ) and FANCN ( PALB2 ), have also been identified as rare breast cancer susceptibility genes.[182] For more information, see the Cancer Risks, Spectrum, and Characteristics section in BRCA1 and BRCA2 : Cancer Risks and Management, or see the BRIP1 , PALB2 , and RAD51 sections in Genetics of Breast and Gynecologic Cancers

Oxidative stress then accelerates the aggregation of -synuclein which subsequently binds and sequesters available GSH, creating a destructive feedback loop of protein misfolding and antioxidant loss (Hoepken et al., 2007)

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The + 4-oxidation state of Mn in MnO imparts strong oxidative properties, enabling its responsiveness to reducing agents like GSH, allowing it to be rapidly reduced and degraded by GSH