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Description

The protective effect of PNU-282987, a selective alpha7 nicotinic acetylcholine receptor agonist, on the hepatic ischemia-reperfusion injury is associated with the inhibition of high-mobility group box 1 protein expression and nuclear factor kappaB activation in mice

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The most common severe adverse events (grade 3 or 4) were hypertension, increased liver enzymes, hyponatremia, and diarrhea [34]

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There are still no clinical trials

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