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Increased Energy Expenditure Activation of the glucagon receptor contributes to enhanced fat burning and energy utilization, meaning Retatrutide can promote calorie expenditure independently of exercise, complementing its appetite-suppressing effects for more effective body composition improvements

In TRIUMPH-4 the discontinuation rates were higher, which investigators noted correlated with baseline BMI and with discontinuations for perceived excessive weight loss [10]

2009;21(6):609-e22

Retatrutide has balanced agonism at all three receptors, distinguishing it from tirzepatide (dual GIP/GLP-1) and semaglutide (selective GLP-1)