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This combined approach results in improved glycemic control and substantial weight reduction, with clinical trials demonstrating HbA1c reductions of 1.9% to 2.4% and weight loss of approximately 15% to 22% of body weight at the highest doses in specific trials such as SURMOUNT-1

Constant nausea can cause vomiting and an electrolyte imbalance

Without proper monitoring, that calorie deficit may accelerate lean muscle loss alongside fat

Subcutaneous injection produces a half life closer to three hours because the peptide enters circulation gradually through capillary absorption, bypassing immediate hepatic degradation