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Schroth W, Goetz MP, Hamann U, et al
In summary, NRF2 activation ameliorates liver fibrosis by interfering with HSC activation through modulating TGF- signaling, downregulating fibrogenic mediators, suppressing inflammation, reducing oxidative stress, and epigenetic regulation
il miglioramento della fibrosi di almeno un grado stato osservato nel 24,2% e 25,9% dei trattati, rispetto al 14,2% del placebo (Harrison et al., 2024)
Figure 2 Interestingly, many of the initial studies elucidating NRF2-ARE-mediated cellular protection utilized tert -butyl hydroquinone (tBHQ), a synthetic antioxidant and inducer of the NRF2 pathway via its auto-oxidized, electrophilic form tert-butyl benzoquinone (tBQ) (Rushmore and Pickett, 1990
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