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The future lies in developing allosteric modulators or subunit-selective antagonists (particularly for GluN2B-containing receptors) that can precisely modulate pathological hyperactivity in the auditory pathway without disrupting essential NMDA receptor functions elsewhere in the brain, thereby offering a more effective and tolerable treatment strategy for tinnitus (Rafe et al., 2024

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Abe R., Katoh N., Takahashi Y., et al., Distribution of Amyloidosis Subtypes Based on Tissue Biopsy Site Consecutive Analysis of 729 Patients at a Single Amyloidosis Center in Japan, Pathology International 71, no