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Down-regulated activities of CBS and CSE of the pathway confirmed the speculation and therefore led to their conclusion that high-fat-induced down-regulation of hepatic transsulfuration activity caused plasma homocysteine elevation, which was likely to contribute to the increased risk of cardiovascular disease associated with the condition [33]

Leucas zeylanica, which is used in traditional medicine for the treatment of GA, can also improve GA inflammation by reducing the metabolite levels through the inhibition of the AA lipoxygenase pathway (225)