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This occurs even in severely impaired conditions, such as in advanced and poorly controlled irritable bowel disease, in which it stimulates expression of genes responsible for cytokine and growth factor generation and also extracellular matrix (collagen) formation, along with intestinal anastomosis healing, reversal of short bowel syndrome and fistula healingall of which can extremely frustrating issues in people who have gut pain, constipation, diarrhea, and bowel inflammation.

Acknowledgments The authors would like to express their gratitude to all the patients and healthy volunteers who participated and all the staff who helped with recruitment

Rossini, M., Di, Munno O., Valentini, G., Bianchi, G., Biasi, G., Cacace, E., Malesci, D., La, Montagna G., Viapiana, O., and Adami, S