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ER stress and UPR are recognized to be important regulators of chondrocyte behaviour, as gene mutations of extracellular matrix proteins or disruption of the UPR pathway result in chondrodysplasia phenotypes 13,14,15,16

Most treatments show noticeable improvements within a few weeks, but optimal results may require multiple sessions

These often include: a body mass index (BMI) above a certain threshold weight-related health conditions referral through specialist services Because access through the NHS can be restricted, many people obtain GLP-1 medications through private clinics or online pharmacies

The question driving this research is a compelling one: could restoring healthy tissue in the duodenum get these signaling pathways working normally once again