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One of the main sites of absorption is the red blood cells
Approach Phase 2b trial arm Duration 24 weeks Review Point Week 12 and 24 Notes METAOD006 (OPTIONS) used 24 weeks at oral doses 0.25, 0.5, or 1 mg/day in 502 obese adults
We actually prefer SQ because its painless and has an established track record of effective B12 delivery, whereas IM can be painful and tends to put people off self-injecting
So I think the promise here is a medication that gives us moderate weight loss, which is sufficient in the majority of our patients to improve their health, to meet our patients needs for weight loss, to meet our health goals in terms of preventing and treating obesity-related complications with a well-tolerated medication
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