These studies have only examined one form of reduced folate, folinic acid, and have only examined treatment response in limited studies

: 10 2250 Water, Glycerin, Dipropylene Glycol, Propanediol, Hippophae Rhamnoides Water, Caprylic/Capric Triglyceride, PPG-13-Decyltetradeceth-24, Hydroxyacetophenone, Caprylyl Glycol, Carbomer, Tromethamine, Hydrogenated Lecithin, Glutathione(600 ppm), Cetearyl Alcohol, 1,2-Hexanediol, Disodium EDTA, Stearic Acid, Dipotassium Glycyrrhizate, Terminalia Ferdinandiana Fruit Extract, Butylene Glycol, Lecithin, Pentylene Glycol, Acetyl Glutamine, Sodium Hyaluronate, Polyglyceryl-10 Stearate, Panthenol, Folic Acid, Bacillus/Soybean Ferment Extract, Oligopeptide-1, Hexapeptide-11, Oligopeptide-2, Oligopeptide-3, Sodium Ascorbyl Phosphate, Hydrolyzed Pea Protein, Madecassoside, Phytosterols, Squalane, Olea Europaea (Olive) Fruit Oil, Tocopherol, Niacinamide, Hyaluronic Acid, Hydrolyzed Hyaluronic Acid, Hydroxypropyltrimonium Hyaluronate, Hydrolyzed Sodium Hyaluronate, Potassium Hyaluronate, Ceramide NP, Butyrospermum Parkii (Shea) Butter, Ethylhexylglycerin, Biotin, Sodium Hyaluronate Crosspolymer, Pyridoxine, Cyanocobalamin, Riboflavin, Thiamine HCl, Retinol, Bioflavonoids, Sodium Acetylated Hyaluronate, Menadione, Acetyl Hexapeptide-8, Copper Tripeptide-1, Palmitoyl Pentapeptide-4, Linoleic Acid, Beta-Carotene, Fragrance , 10-20 ,

Patients interested in these options can usually find information through the official medication websites
The reduced refolding by the chaperone is possibly due to the inability of these Syn variants to adopt the native tertiary inert state, causing prolonged chaperone engagement