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One side effect that often goes undiscussed, however, is semaglutide fatigue
It is important to clarify that, whereas population-level PRS models require formal effect-size modeling, linkage disequilibrium correction, ancestry calibration, and validation across large cohorts, the score used in this workflow is a functional polygenic score (PRS-F) designed for mechanistic, individual-level interpretation rather than for epidemiological prediction
Compounded versions of semaglutide and tirzepatide also need to be reconstituted before use, adding another step
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