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For others, food alone is a reasonable pathway to success

Glucagon-like peptide-1 (GLP-1) is a physiological hormone that has multiple actions on glucose, mediated by the GLP-1 receptors

We previously showed that GIPR activity in alpha cells potentiates amino-acid-stimulated glucagon secretion in mouse islets 11 , and here we found the same interaction between hGIP and amino acids in human islets using concentrations of amino acids found in the postprandial state (Extended Data Figure 4) 11 , prompting us to ask whether tirzepatide engagement of the GIPR in human islets also enhances the effect of amino acids on glucagon secretion

The goal is to lose fat while preserving as much lean mass as possible," she tells Parade